Relocation of BBCs worth for income watchdog costs £3.2m

THE watchdog entrusted with mending worth for income from the BBC for licence-payers has outlayed �3.2 million on new premises. The BBC Trust sealed a �2.2m eight-year franchise for the new domicile in executive Londons Great Portland Street – one of the capitals majority disdainful addresses.Another �1m was outlayed on refurbishing the building, of that some-more than 40 per cent – ADVERTISEMENT�400,000 – was outlayed on "construction and fit out", and a entertain – �250,000 – on design, plan government and removals.The certitude deserted space in offices used by the house at beside Broadcasting House and at the BBCs Television Centre in White City, west London.Between 40 and 50 members of the watchdogs 60-strong staff are right away housed in the converted Edwardian mansion. They changed from old offices in Marylebone High Street in Oct last year as piece of the corporations "property portfolio consolidation".The BBC insisted the trusts preference represented "best worth for money" and pronounced it had deliberate an additional twelve properties prior to settling on Great Portland Street.It pronounced the "physical separation" from alternative BBC departments was additionally critical in assisting the certitude strengthen the independence.The move – that came shortly after enlightenment cabinet member Ben Bradshaw referred to the watchdog as a "cheerleader" for the BBC – is written to save licence-payers around �300m, according to a certitude spokesman. He said: "The BBC Trusts bureau move was not done in siege and was a outcome of the BBCs wider skill portfolio consolidation. Ending the franchise on Marylebone High Street, where the certitude was formerly based, along with BBC London and Training and Development, will emanate �300m of assets for looseness price payers."The trusts stream bureau in Great Portland Street was selected on the basement that it offering the most appropriate worth for income of all the options considered, and we have reused and recycled existent bureau seat and apparatus in the fit-out of the new premises as far as possible."The Conservatives have affianced to disintegrate the certitude in foster of a physique "more in balance with looseness price payers", should they win the ubiquitous election.

Haiti assist bid injured by delayed U.N. reply

Tom Brown PORT-AU-PRINCE Fri Feb 26, 2010 1:13pm EST Related News Haiti preserve puncture as sleet turns camps to mudThu, Feb eighteen 2010U.N. assist arch chides agencies on Haiti reliefThu, Feb eighteen 2010Sarkozy visits Haiti, unveils vital assist packageWed, Feb seventeen 2010Tarps, toilets are priorities for quake-hit Haiti: U.N.Mon, Feb fifteen 2010One month after quake, Haitians stick on to weep deadFri, Feb twelve 2010 < 1 / 7 >

PORT-AU-PRINCE (Reuters) - Clutching involuntary attack rifles, truckloads of U.N. infantry patrolled the streets of Haiti"s cracked collateral on the day after the trembler strike last month, clearly preoccupied to the wretchedness around them.

World&&&&Natural Disasters

Cries for assistance from people digging for survivors in collapsed buildings were drowned out by the bark of heavy-duty engines as the infantry plowed by Port-au-Prince but interlude to stick on rescue efforts, majority less lead them.

A usual steer since they were deployed in 2004, the U.N. infantry huddled in the shade of their canopied vehicles.

There were about 9,000 uniformed U.N. peacekeepers stationed in Haiti when the upheaval struck on Jan twelve and they were the judicious "first responders" to the mess in the bankrupt Caribbean country, whose notoriously diseased executive supervision was impressed by the scale of the tragedy.

Initially, however, nothing of the peacekeepers appeared to be concerned in hands-on charitable service in what puncture healing experts report as the vicious initial 72 hours after a harmful trembler strikes.

Their reply to the abominable pang was singular to you do security and seeking for looters after the bulk 7.0 upheaval intended majority of the collateral and took what Haitian President Rene Preval says could be as majority as 300,000 lives.

There was looting in the capital, but it paled in some-more aged with the astringency of the charitable crisis.

Horribly-injured patients flooded overstretched hospitals, forcing healing staff to confirm that patients to yield and that were already as well far left to try saving.

"Doctors played God," pronounced Tyler Marshall, a maestro former Los Angeles Times match operative with an general assist organisation that helped out in a tent city erected at the tallness of the destruction on the drift of Port-au-Prince"s University Hospital, the country"s largest.

Scores of U.N. crew died in the quake, together with Hedi Annabi, head of the U.N. mission that was set up in 2004. That helps insist what majority have criticized as a glacially delayed kickoff of service operations after one of history"s misfortune healthy disasters.

But in the days and weeks that followed it mostly seemed that lessons from alternative disasters were abandoned in Haiti as fears of rioting or anarchy overshadowed concerns about removing assist out quickly.

The U.N."s tip charitable assist official, John Holmes, is between those who have chided service agencies, together with the United Nations itself, for you do as well small to assistance Haiti.

"We cannot ... wait for for for the subsequent puncture for these lessons to be learned," Holmes wrote in a trusted email initial published on the website of the biography Foreign Policy.

"There is an obligatory need to progress significantly genius on the ground, to urge coordination, vital formulation and sustenance of aid," pronounced Holmes.

Edmond Mulet, behaving head of the U.N. mission, concurred in an talk that it played a singular charitable purpose in the initial couple of days after the trembler since the operations were effectively decapitated.

"At the unequivocally commencement it was unequivocally formidable since all the domicile was utterly broken and all the care of the mission was killed," Mulet told Reuters.

"CRIMINALS AND BANDITS"

Mulet gained prominence for wielding an iron fist during a prior army as head of the U.N. mission when he led mostly Brazilian "blue helmet" infantry in a successful crackdown on Haiti"s heavily armed gangs.

And he has finished no tip about sophistry the competing needs of service operations with law enforcement, in his bid to lane down the some-more than 3,000 inmates who took value of the trembler to shun from the main prison.

"We are here additionally to yield security," he pronounced when asked about the mess of convoys of rifle-wielding U.N. infantry to poke for people trapped in the rubble of the busted capital.

"I still have to patrol, I still have to go after all these criminals and bandits that transient from the inhabitant penitentiary, the squad leaders, the criminals, the killers, the kidnappers. I cannot unequivocally confuse myself from you do that."

The service mission shifted in to higher rigging after U.S. infantry deployed in large numbers and set up a supply sequence to get food and disinfectant in to areas great out for aid.

But there were still majority bottlenecks and setbacks, mostly involving U.N.-linked food distributions hobbled by unsound organization, reserve and throng control.

Unfortunately, U.N. infantry in Haiti have over the years gained a repute for toughness and abuse some-more than for easing pang in the lowest nation in the Americas.

"The usually time I"ve seen one of these U.N. infantry burst out of the behind of a lorry was to kick up on somebody or take a shot at them," pronounced a piece of the U.S. Army"s 82nd Airborne Division, as he worked security during a new assist handout.

"These guys have since all of us in unvaried a bad repute here," he said, asking not to be identified.

Haiti"s wrecked infrastructure and bad ride links finished it formidable to get assist out and keep it flowing, but that frequency finished the incident opposite from that in alternative new disasters around the globe.

"POOREST AND MOST VULNERABLE"

"The lowest and the majority exposed people lend towards to live in the regions that are strike the majority by healthy disasters," pronounced Solomon Kuah, an puncture healing medicine formed in New York who outlayed 4 weeks in Port-au-Prince after the quake.

There are no arguable estimates for the series of survivors who died from injuries due to unsound healing supplies.

But Henriette Chamouillet, the World Health Organization"s deputy in Haiti, pronounced all from staff shortages to bureaucracy and a miss of make-up lists embroiled the smoothness of containers full of medicines from Port-au-Prince"s airfield to doctors on the ground.

Port-au-Prince sits usually 700 miles off the seashore of Miami, that is home to a large Haitian-American community, and it seemed ludicrous that so couple of the U.S. infantry rushed there spoke French or were accompanied by translators.

One retaining picture of pell-mell food distributions came when U.S. helicopters offloaded boxes of MREs (Meals Ready to Eat) at a site in the capital. Many Haitians non-stop them up usually to toss them afar in offend since no French or Creole-language instructions were enclosed with the assumingly invalid packets of dust, explaining that they indispensable to be churned with H2O as piece of their preparation.

Rajiv Shah, head of the U.S. Agency for International Development, has touted the Haiti service mission as "the largest and majority successful general poke and rescue bid ever fabricated in history."

But some-more than 6 weeks after the upheaval hit, the mission is still mostly in an puncture reply mode. The U.N."s World Food Program is tying the food rations to 55-pound (25 kg) bags of rice and the Haitian supervision estimates that a million upheaval survivors are still vital in the streets in temporary encampments with no using H2O or toilets.

Doctors are roughly finished traffic with dire injuries but reconstruction for a little 40,000 amputees and rebuilding Haiti"s health infrastructure are between long-term challenges.

"This is unequivocally a mess of Biblical proportions," pronounced Lewis Lucke, who was the USAID executive in Iraq prior to entrance to Haiti as U.S. ambassador.

U.N. and alternative officials have pronounced the tellurian reply to Haiti"s upheaval was quicker and some-more in effect than in alternative new disasters, together with the Asian tsunami that killed 226,000 people in thirteen countries in Dec 2004.

But experts contend the United Nations has a lot to sense from smaller, some-more nimble healing groups similar to International Medical Corps, or IMC, and Paris-based Medicins Sans Frontieres, along with charities some-more experienced in distributing aid, such as CARE and Catholic Relief Services.

Kuah, who concurrent service efforts for IMC, a California-based organisation that had rarely learned doctors treating patients in Haiti twenty-three hours after the trembler struck, stressed the "need for speed" when it comes to saving lives.

"When you ask yourself if there were ways you could have prevented some-more mortalities or discontinued additional mortality, with earthquakes, in particular, it"s some-more timing than anything else," pronounced Kuah.

(Additional stating by Catherine Bremer, Jackie Frank, Patricia Zengerle, Mica Rosenberg and Andrew Cawthorne; Editing by Kieran Murray)

World Natural Disasters lampshade for acne to phone help this mulls

Nervous retailers condense prices over Easter break

Jenny Davey & ,}

Britain"s greatest retailers are slicing prices by half this Easter in a desperate try to convince shaken consumers to outlay among joyless holiday weather.

Asda, the supermarket giant, is perplexing to captivate shoppers by charity renouned beer and lager brands for as small as 10 for twenty-four cans.

The monster discounting has lifted fears of a unpleasant choosing run-up for retailers. Growing excitability about taxation rises, total with the wintry weather, have put most family groups off spending, denting retailers sales and profit margins.

Its as infamous as Ive ever seen it, pronounced one heading tradesman this weekend. Business is tougher, Vat is behind on, the choosing is entrance and customers are disturbed about taxation rises. There is a outrageous quarrel for marketplace share.

Related LinksSainsburys annals lowest expansion in five yearsEaster trading: A time for home improvement

The big supermarket bondage are at the forefront of the discounting in both food and ubiquitous merchandise.

J Sainsbury is charity half-price booze and half-price lamb, gammon and pig joints. Tesco is using promotions on salmon and lamb and has slashed the price of most non-food items, together with electrical goods.

Debenhams is holding a half-price sale, and Argos has cut the cost of most popular radio sets by up to a third. Focus, the DIY retailer, is offering half-price on all kitchens and bathrooms and an additional 20% off for the Easter break.

The discounting comes as sell sales appeared to rebound behind in Feb after a difficult January. The British Retail Consortium (BRC) pronounced like-for-like sales were up 2.2% compared with the 0.7% tumble seen in January, when sleet put off shoppers. But the BRC was discerning to point out that the sales total compared with really diseased trade in Feb last year. Food sales were additionally sluggish, flourishing at their slowest rate given 2007.

The City will take a close seductiveness in remarks about stream trade from Sir Stuart Rose, senior manager authority of Marks Spencer, when the tradesman reports fourth-quarter total this week.

Analysts are awaiting great headlines from MS after shoppers rushed out to buy coats and knitwear during the winter freeze. Rose, however, is likely to paint a discreet design about consumer spending for the rest of this year.

City analysts design that MS will broach a 1.7% climb in underlying sales for the thirteen weeks to Mar 27, up from 0.8% in the prior quarter. About 70,000 MS staff are approaching to share an estimated 80m reward pool, reception an average remuneration of 500 each.

The Labour declaration at a glance

Here are the key points from Labours General Election declaration 2010, A Future Fair For All.

* Secure the liberation by ancillary the economy and halving the necessity by 2014 by growth, satisfactory taxes and cuts to reduce priority spending.

* Will not lift basic, higher and new tip rates of taxation in the subsequent Parliament.

* No prolongation of VAT on food, childrens clothes, books, newspapers and open ride fares.

* Realise stakes in publicly-controlled banks, deliver a tellurian levy and remodel promissory note rules.

* Create UK Finance for Growth, bringing �4 billion together to yield collateral for flourishing businesses.

* Up to 70,000 modernized apprenticeships a year and Skills Accounts for workers to ascent their skills.

* Create one million learned jobs and modernize infrastructure with high speed rail, a immature investment bank and broadband entrance for all.

* No stamp avocation for first-time buyers on all residence purchases next �250,000 for dual years, paid for by a 5% rate on homes value some-more than �1 million.

* Require a super-majority of two-thirds of shareholders in corporate takeovers.

* Job or precision place for immature people out of work for 6 months but benefits cut at ten months if they exclude a place. Guarantee of work for any one impoverished for some-more than dual years.

* National Minimum Wage to climb in line with normal earnings.

* Ensure value is widespread opposite open services with 1,000 schools to turn piece of high customary accredited schools groups, each sanatorium a Foundation Trust and underperforming military forces or precinct commanders transposed or taken over.

* Right to stop MPs, referendum on the pick opinion for the Commons, referendum on a approved second chamber, free opinion in Parliament on shortening the choosing by casting votes age to 16.

* Help for relatives to change work and family life, with a Fathers Month of stretchable paid leave.

* A new Toddler Tax Credit of �4 a week from 2012 to all relatives of immature children.

* National Care Service to safeguard free caring in the home for those with the biggest caring needs, top on the costs of residential care.

* Re-establish the couple in between the Basic State Pension and gain from 2012.

* An enlargement of free hothouse places for two-year-olds and fifteen hours a week of flexible, free hothouse preparation for 3 and four-year-olds.

* Give relatives the energy to move in new propagandize care teams, by mergers and takeovers, with up to 1,000 delegate schools piece of an accredited schools organisation by 2015.

* Every immature chairman on trial preparation or precision until 18, with 75% going on to higher education, or completing an modernized tutelage or technician turn training, by the age of 30.

MySpace readies site renovate to rekindle expansion

Alexei Oreskovic SAN FRANCISCO Wed March 10, 2010 12:10pm EST Related News Yahoo partners with Twitter to progress amicable featuresWed, February twenty-four 2010Yahoo partners with Twitter to progress amicable featuresTue, February twenty-three 2010

An undated picture pleasantness of MySpace.

Credit: Reuters/Handout

SAN FRANCISCO (Reuters) - With timorous audiences, low layoffs and dual government shake-ups, MySpace, the one-time celebrity in Internet amicable networking, has had a hilly year.

Technology&&&&Media

Mike Jones, who took over as co-president last month with Jason Hirschhorn, pronounced that even inside of MySpace a little employees have lost the will to keep fighting.

"We are at the point right away where we need believers," pronounced Jones, observant that the News Corp section has speedy assorted people not entirely committed to the means to leave and has hired new talent.

The need for conviction speaks to the range of the plea confronting MySpace. With foe from sepulchral amicable networks identical to Facebook and Twitter, and Google Inc jumping in to the fray, MySpace hopes to turn the initial amicable network to recover the mass appeal.

At the company"s Beverly Hills domicile on Monday, Jones and Hirschhorn summarized their plan for the initial time given reception the reins as co-presidents. They pulled the screen behind on a new version of the site that will be rolled out in installments over entrance weeks and months.

The new site recasts MySpace some-more strongly around the song and media content, with facilities such as the capability to attend to a song playlist formed on songs that alternative MySpace users are pity in their tide of updates.

The idea is to coax expansion between new users and to captivate behind users that have departed, says Hirschhorn.

"We do not wish to stay at 100 million (users) or 120 million. We wish to grow to 200 million or 300 million," Hirschhorn said, though he declined to give a time await for achieving those numbers.

MySpace had 119.6 million singular visitors worldwide in Jan 2010, down 7.4 percent year-over-year (though up from the Nov low of 108.1 million), according to ComScore.

While those appear identical to critical numbers, Facebook says it right away counts 400 million active users.

Hirschhorn, a former senior manager with Viacom Inc"s MTV Networks, assimilated MySpace in Apr 2009 as Chief Product Officer, piece of a new government group that brought in Jones as Chief Operating Officer and Owen Van Natta as CEO. Less than 10 months later, Van Natta is gone, due to what a source close to the association pronounced was a celebrity dispute between the trio. Van Natta couldn"t be reached for comment.

The dual new co-presidents would not criticism on the shake-up, but pronounced the revamp of the site right away being introduced is in keeping with the plan all 3 management team devised over the past eleven months, together with the Aug 2009 merger of Internet song pity use iLike.

Analysts contend construction on MySpace"s strength in song and party is a essential strategy, though a little consternation either the association will be means to emanate a singular charity among a raft of rivals with identical goals, from Yahoo Inc, and music-service Pandora to Facebook.

And they advise comebacks are singular in the Web business.

"When you see at the alternative amicable networks that have faltered, they finish up being a special fool around for a sold culture," Jeremiah Owyang, a partner at Web consulting organisation Altimeter Group pronounced on Monday. He cited Friendster, a amicable networking colonize that lost belligerent to Facebook and MySpace and right away caters to users in Southeast Asia.

SEARCHING FOR A DEAL

One of the evident hurdles confronting the dual new presidents is replacing the three-year, $900 million poke promotion understanding with Google that expires in Aug 2010.

The drop-off in MySpace trade already has resulted in the association reception lower-than-expected payments from Google, and analysts contend any new understanding will be on far less auspicious terms.

Jones, who has led negotiations with Google, would not criticism on either MySpace would need to change the cost make up if the subsequent poke understanding yields less revenue. But he was assured MySpace wouldn"t have difficulty anticipating a partner or partners, meddlesome in offered ads to the audience.

Some analysts additionally consternation either MySpace, that News Corp acquired for $580 million in 2005, competence be improved off on the own as it vies with companies focused particularly on the Web business, majority of that are privately-held and underneath less vigour from shareholders to broach quarterly results.

"For majority Internet companies, the majority critical thing is to be means to be conform and be discerning to move in a fast becoming different market, and infrequently that could be detained by being piece of a incomparable company," Ryan Jacob, of the Jacob Internet Fund pronounced on Tuesday. The Jacob Internet Fund does not own News Corp shares.

However, Jacob pronounced that the monetary await News Corp provides, and the doors it can open to partnerships, could infer beneficial to a association perplexing to reconstruct the business.

Hirschhorn pronounced MySpace was underneath no vigour to encounter monetary goals at the responsibility of prolonged tenure strategy.

"We"re a business, this isn"t Unicef. Of march we"re focused on monetization," pronounced Hirschhorn.

News Corp"s priority was mending MySpace and rebuilding the audience. "If we don"t urge this product there"s not going to be anything at the finish of the road," he said.

(Editing by Edwin Chan; modifying by Carol Bishopric)

Technology Media

Once on a time The most appropriate childrens books from time to go to bed stories to assistance with potty training... Books

Best for comparison toddlers: "The Gruffalo" by Julia Donaldson and Axel Scheffler

Over 4 million copies of this contriver story have sole worldwide given the announcement in 1999 and with good reason. It is talented and lively as well as being beautifully created and illustrated. It is, in short, a complicated classical and, as such, has won over a multitude of fans immature and old as well as countless awards. Last year, it even done the big screen. Worthwhile investments between the outrageous form of Gruffalo sell embody the audio-book review by Imelda Staunton, The Gruffalo Jigsaw Book, The Gruffalo Magnet Book and, majority appropriate of all, The Gruffalo Pop-up Theatre Book.

Macmillan: �5.99

Best droll book: "Pants" by Giles Andreae and Nick Sharratt

This award-winning toddlers book is a jubilee of pants frilly ones, uneven ones, big and small ones and majority more. It is a contingency for any family with a clarity of humour. And if you feel you need a tad some-more tutorial worth in the books you buy for your offspring, fright not as it offers a wider perspective of the world. We challenge any toddler not to venerate it.

Random House: �5.99 (paperback)

Best journey book: "We"re Going on a Bear Hunt" by Michael Rosen

This book has a appeal all of the own. Follow the familys fad as they wade by the grass, dash by the stream and crush by the sand in poke of a bear. What a warn awaits them in the cavern on the alternative side of the dim forest. Michael Rosens story is playfully created and the illustrations by Helen Oxenbury honestly constraint the feeling of being outdoor in all weathers. Magical.

Walker: �5.99

Best book to assistance your kid by a new experience: "Boys" Potty Time" and "Girls" Potty Time"

With a singular potty-shaped cover, these shining toilet-training books are undiluted for assisting your kid have the passing from one to another from nappies to pants. Full of fun rhymes and cinema that show your kid how to have use of their potty, the Potty Time form is an glorious investment. Bright colours and photography have the books lively for immature children, and fun and accessible recommendation helps to take the be concerned out of potty precision for relatives and toddlers alike. Each book includes a piece of special prerogative stickers.

Dorling Kindersley: �4.99 each

Best for younger toddlers: "Thats Not My Puppy..." by Fiona Watt

No kid should go by their decline but at slightest one of the 31 books in this award-winning series, that ranges from Thats Not My Puppy to Thats Not My Fairy. Each combines bright, desirable illustrations with a accumulation of opposite textures to hold and feel on each page as well as reassuringly steady text. It helps immature young kids to rise critical denunciation and feeling skills as well as removing them meddlesome in books generally.

Usborne: �5.99

Best personalised book: "Now You Are Two" by Holly Wright

Toddlers mostly love zero some-more than seeking at themselves in a counterpart and conference elementary stories about themselves. Itsyourstory was one of the initial companies in the UK to suggest print personalised books, and has the largest and arguably the majority appropriate peculiarity range. An combined reward of their books that embody The Dressing Up Box and A Trip to the Farm, between majority others is that, once the kid has grown out of the book, it becomes a good memento, all the improved for being well-thumbed. Better still, all the books have a concentration on the childs development, either creation them wakeful of their vicinity or enhancing their self-esteem. A fanciful present for any toddler.

www.itsyourstory.co.uk: �19.99

Best time to go to bed story book: "Goodnight Moon" by Margaret Wise Brown

This is the idealisation relaxing book. By observant goodnight to all in the room even the air young kids are lulled in to a pacific sleep. Its short sufficient for toddlers" courtesy spans, and the rhymes can simply be repeated.

Macmillan: �4.99

Best classic: "The Very Hungry Caterpillar" by Eric Carle

When The Very Hungry Caterpillar detonate on to the stage in 1969, young kids right away took to it, and, whilst the word classical is glued together about by publishers, this book honestly is only that. There are multiform reasons why: the desirable and right away iconic illustrations, the hole in each page that enables your infant to pull his or her corpulent finger by it to impersonate the larva munching by his form of weird foodstuffs, and majority of all the spirit. Only last year, Carle himself called it a book of hope. You can grow up and fly in to the universe with your talents. Many versions have popped up over the years, the majority new being The Very Hungry Caterpillar Finger Puppet Book (�7.99).

Puffin: �5.99 (hardback, mini-board)

Best lift-the-flap book: "Dear Zoo" by Rod Campbell

Rod Campbells Dear Zoo is elementary nonetheless engaging. In short and it is short (and thus undiluted for a sleepy toddlers time to go to bed read) it is a desirable and subtly funny story about wanting to find the undiluted pet. Kids benefit unconstrained pleasure from light the flaps to see the animals, and singular is the domicile where this book doesnt turn an present strike and long-time favourite. For alternative much-loved Rod Campbell books, check out Oh Dear!, Farm 123 and ABC Zoo, that have sole millions of copies worldwide.

Puffin: �5.99

Best heartwarmer: "No Matter What" by Debi Gliori

A small fox is in a big bad mood and is disturbed the mom wouldnt love it forever. In this lively design book, a crafty and quick mom proves to her kid that a relatives love is vast no make a difference what. Its a uninformed and beautiful diagnosis of the informed theme of childhood worries that award-winning writer and illustrator Debi Gliori seems to undiluted probably since she was desirous to emanate the book to encourage her daughter of her love for her. Its been called the well read homogeneous of a big hug, and justly so.

Bloomsbury: �4.49 (paperback)

Personalized disinfectant for cancer patients in a new record era

Formed in 2008, the consortium brings together heading cancer researchers from around the world, operative together to catalog the genetic changes of the 50 infancy usual cancers -- 500 genomes from each cancer sort -- and have the formula openly accessible on the internet.

Given the extensive intensity for comparatively low-cost genomic sequencing to exhibit clinically utilitarian information, we expect that in the not so faraway future, prejudiced or full cancer genomes will customarily be sequenced as piece of the clinical research of cancer patients, contend the authors in the paper.

Their matter is sincerely low-key, since the towering scale of swell over the last integrate of decades. The primary human genome project, that sequenced half a dozen people, cost 1.5 billion dollars and took fifteen years. The same volume of interpretation can right away be processed in a week at a fragment of the cost.

This is already revolutionising the proceed we do cancer research, pronounced Professor Andrew Biankin, part of the Nature paperwriting team, researcher at SydneyGarvan Institute of Medical Research, surgeon at SydneyBankstown Hospital and co-leader of the Australian Pancreatic Cancer Genome Initiative, the Australian plan arm of the ICGC.

The plea in the past was to beget information. The plea right away is to conduct the volume being generated every day -- anticipating ways to interpret, exam and ask it appropriately.

The consortium is on condition that the tellurian investigate village with the majority suitable probable investigate apparatus -- how to name the subsequent clinical trial. Whole genome sequencing allows us to pinpoint the expect molecular aberrations of each tumour. Understanding the aberrations allows you to aim them with drugs.

For example, you competence find that the aberrations in a subtype of colon cancer are the same as the aberrations in a subtype of melanoma. In that case, the diagnosis that functions in the colon cancer competence be suitable for the melanoma. So you"d go forward and exam it.

The complaint we have is the complexity of cancer. No dual tumours are the same, even inside of the same sort of cancer. They competence see the same underneath the microscope, but their molecular aberrations change greatly.

When we provide a cancer, we give a chairman the drug thatmost expected to work -- inside of the stipulations of the stream understanding. The drug competence not work for that individual, even though it functions for the infancy of patients with the same kind of cancer. If the diagnosis fails, we go onto the second-line treatment, that competence additionally fail. By the time we get to the diagnosis thatactually going to work, it competence be third or fourth down the line and the cancer competence have advanced. In the box of pancreatic cancer, the studious has probably died.

The consortiuminternet-based databanks will assistance us provide specific cancers with specific treatments. Not usually that, the report will assistance us assimilate because a little treatments work and others do not, and afterwards pattern improved drug to aim inadequate elements or mechanisms.

One of the primary things we can do is collect the low unresolved ripened offspring -- things not rescued by the old technologies. For example, if an existent care targets molecular aberrations in one cancer type, nonetheless the goods have not been explored in alternative cancer types, we right away have a fast proceed of identifying that of the unexplored cancers is a expected new target.

B-RAFF inhibitors are a great e.g. of a drug that shows guarantee for treating a little kinds of melanoma. If you were to exam the drug with 50 alternative cancers, it could take 50 years, utilizing old methods and technologies.

If you proceed the complaint with new technologies, you can fast compare the drug with molecular aberrations in specific cancers, and slight the hearing proviso down to a couple of months.

Australiaand Canadapancreatic plan groups will be between the primary to recover primary interpretation on the web, to one side the UK (breast cancer), China (gastric cancer) and Japan (liver cancer). The interpretation recover and web entrance is timed to happen at the same time with the announcement of the Nature paper.

There will be assorted tiers of access, with reliable discipline and governance in place to umpire who can see what. The ubiquitous open will be means to see ubiquitous summaries, whilst members of the investigate village will be means to ask minute reports, depending on their needs.

Pancreatic cancer sequencing in Australia will be undertaken by Professor Sean Grimmond from the University of QueenslandInstitute for Molecular Bioscience in Brisbane, co-leader of the Australian group with Professor Biankin. (See sum of the Australian arm of the ICGC plan below.)

We"ve only finished a handful of sequences -- and already we know for certain that genuine cancer looks almost opposite from the cell lines we"ve been utilizing in the lab, pronounced Biankin.

We"ve hypothesised about that in the past, but carrying the justification to infer the disproportion is exciting. Right from the opening we know all there is to know about one persontumour at the genomic, transcriptomic and epigenomic levels. We competence not assimilate it, but we"ve got the data.

While not described in the paper, Biankingroup is utilizing mice to host slices of human pancreatic tumour, effectively using make up clinical trials in the animals.

Itgreat that we have the sequencing report as it allows us to run these together human-type trials in mice, contrast a range of drug opposite the specific molecular targets we know to exist in the tumour. It saves decades you do genuine clinical trials in people.

While researchers have practical xenografts to mice in the past, they have not had the resources or report to run tests as quickly or evenly as this.

AustraliaContribution to ICGC

Australia is creation a estimable accede to to the International Cancer Genome Consortium by rebellious pancreatic cancer, one of the deadliest cancers and fourth infancy usual means of cancer death.

The Australian group is being led by Professor Sean Grimmond from the University of QueenslandInstitute for Molecular Bioscience in Brisbane and Professor Andrew Biankin from the Garvan Institute of Medical Research in Sydney. It additionally involves collaborative contributions from the Walter and Eliza Hall Institute of Medical Research in Melbourne, Johns Hopkins University in Maryland, the Ontario Institute for Cancer Research and the University of California, San Francisco.

The plan is being saved by the National Health and Medical Research Council of Australia (NHMRC), and at $27.5 million it is the largest singular accede to the NHMRC has ever awarded. Further await is being supposing by The Cancer Council NSW, the Queensland Government, the Garvan Institute and the University of Queensland. Applied Biosystems Inc. and Silicon Graphics, large general companies specialising in gene countenance form research and high opening computing systems respectively, are additionally creation poignant contributions.

U.S. appeals justice manners for eBay in Tiffany squabble

Grant McCool and Alexandria Sage NEW YORK/SAN FRANCISCO Thu April 1, 2010 7:25pm EDT Related News CORRECTED - UPDATE 2-US justice manners for eBay in Tiffany heading tiffThu, April 1 2010Kijiji begone: EBay rebranding U.S. personal siteTue, March thirty 2010Philadelphia publisher"s lenders interest bid rulingTue, March thirty 2010Galleon owner wins stay of wiretaps in polite caseWed, March twenty-four 2010U.S. decider manners opposite Citi in Terra fit over EMIWed, March twenty-four 2010

NEW YORK/SAN FRANCISCO (Reuters) - EBay Inc did not rivet in heading transgression and dilution by offered tawdry Tiffany Co products on the website, a U.S. appeals justice ruled on Thursday, but it systematic serve examination of the jeweler"s explain of feign advertising.

U.S.&&&&Technology&&&&Media

Tiffany and alternative oppulance brands have prolonged argued that tawdry sell temperament their names is sole on eBay. The Web custom company, that does not itself put the products up for sale, says it has outlayed millions of dollars to lane down counterfeiters and remove such listings.

The box was seen as a vital plea in the United States to the leisure of Web companies from eBay to Google Inc, that explain that they are merely hosting services, and any heading transgression lies with others, not them. Google won a vital heading feat in the European Union over identical claims last month.

Tiffany pronounced it would cruise an interest to the U.S. Supreme Court and that the preference "leaves in place a prior to statute that allows eBay to distinction from tawdry sales."

The justice signaled that eBay met the responsibilities in the partnership with code holders, pronounced Sally Abel, an profession who chairs Fenwick West"s heading organisation and was not a celebration in the case.

"It"s a win for e-commerce," pronounced Abel, adding that the statute helps interpretation "the need for the online marketplace to have manners and to strengthen heading rights up to a point -- but usually up to that point."

A row of judges on the U.S. Court of Appeals for the 2nd Circuit in New York listened verbal arguments in the brawl last year over Tiffany"s claims, that antiquated behind to 2004.

"It is loyal that eBay did not itself sell tawdry Tiffany goods; usually the feign vendors did, and that is in piece since we interpretation that eBay did not transgress Tiffany"s mark," the appeals justice perspective said. "But eBay did affirmatively publicize the products sole by the site as Tiffany merchandise."

Tiffany indicted eBay of feign promotion since the website touted Tiffany goods, but most of them were essentially counterfeit. The appeals justice disagreed with the anticipating of the district justice that eBay"s ads were not expected to upset consumers.

"The law requires us to hold eBay under obligation for the difference that it chose insofar as they misled or confused consumers," review the appeals justice ruling.

EBay pronounced in a matter that the statute certified the anti-counterfeiting measures and that it was assured that it would kick the feign promotion claim. It criticized the make use of of courts to solve these issues, observant "we go on to await cooperation, rather than litigation."

BATTLING FRAUD

The perspective was published some-more than dual years after a week-long dais hearing prior to U.S. District Judge Richard Sullivan in late 2007. He ruled in Jul 2008 that eBay was not probable for heading transgression by permitting feign Tiffany products to be sole on the website by individuals. Tiffany afterwards appealed to the higher court.

The appeals justice statute remarkable that eBay and others have "a clever inducement to minimize the tawdry products sole on their websites." Tiffany argued that if eBay were not hold probable solely when infringing equipment are brought to the attention, it will have no inducement to stop the sale of counterfeits.

In the arguments to the court, eBay pronounced it outlayed as most as $20 million per year to conflict rascal on the website, together with customer insurance programs and employees who concentration to one side on anti-infringement issues.

Tiffany shares sealed up 1.6 percent to $48.25 on the New York Stock Exchange on Thursday afternoon. EBay fell 1.47 percent to $26.57 on Nasdaq.

The box is Tiffany Co v eBay Inc, U.S. Court of Appeals for the 2nd Circuit in New York, No. 08-3947.

(Reporting by Grant McCool and Alexandria Sage; Additional stating by Phil Wahba; Editing by Lisa Von Ahn; Gerald E. McCormick and Carol Bishopric)

U.S. Technology Media Bit Defender

WALL STREET JOURNAL BEST-SELLERS

March 11, 2010, 5:19 PM EST

FICTION

1. "House Rules: A Novel" by Jodi Picoult (Atria)

2. "The Help" by Kathryn Stockett (Putnam Adult/Amy Einhorn)

3. "Percy Jackson and the Olympians, Book 5: The Last Olympian" by Rick Riordan (Disney-Hyperion)

4. "Big Girl: A Novel" by Danielle Steel (Delacorte Press)

5. "Fantasy in Death" by J.D. Robb (Putnam Adult)

6. "Diary of a Wimpy Kid" by Jeff Kinney (Amulet Books)

7. "Worst Case" by James Patterson and Michael Ledwidge (Little, Brown)

8. "Diary of a Wimpy Kid: Dog Days" by Jeff Kinney (Amulet Books)

9. "Green Eggs and Ham" by Dr. Seuss (Random House Children"s Books)

10."Abraham Lincoln: Vampire Hunter" by Seth Grahme-Smith (Grand Central Publishing)

11."Diary of a Wimpy Kid: Rodrick Rules" by Jeff Kinney (Amulet Books)

12."Diary of a Wimpy Kid: The Last Straw" by Jeff Kinney (Amulet Books)

13."Split Image" by Robert B. Parker (Putnam Adult)

14."The Cat in the Hat" by Dr. Seuss (Random House Children"s Books)

15."One Fish Two Fish Red fish Blue Fish" by Dr. Seuss (Random House Children"s Books)

NONFICTION

1. "No Apology: The Case for American Greatness" by Mitt Romney (St. Martin"s

2. "Payback Time: Making Big Money is the Best Revenge!" by Phil Town (Crown Business) (NF-H)

3. "Diary of a Wimpy Kid Do-It-Yourself Book" by Jeff Kinney (Amulet Books)

4. "Game Change: Obama and the Clintons, McCain and Palin, and the Race of a Lifetime" by John Hellermann and Mark Halperin (Harper)

5. "The Pacific" by Hugh Ambrose (NAL)

6. "Percy Jackson and the Olympians: The Ultimate Guide" by Rick Riordan (Disney-Hyperion)

7. "Switch: How to Change Things When Change is Hard" by Chip Heath and Dan Heath (Broadway Business)

8. "The Immortal Life of Henrietta Lacks" by Rebecca Skloot (Crown Publishing Group)

9. "Strengthfinders 2.0" by Tom Rath (Gallup Press)

10."Not Without Hope" by Nick Schuyler and Jere Longman (William Morrow)

11."The Politician: An Insider"s Account of John Edwards"s Pursuit of the Presidency and the Scandal That Brought Him Down" by Andrew Young (Thomas Dunne Books)

12."Willie Mays: The Life, The Legend" by James S. Hirsch (Scribner)

13."Lift" by Kelly Corigan (Voice)

14."No One Would Listen: A True Financial Thriller" by Harry Markopolos (John Wiley & Sons)

15."Have a Little Faith: A True Story" by Mitch Albom (Hyperion)

The Wall Street Journal"s list reflects national sales of hardcover books during the week finished last Saturday at some-more than 2,500 Barnes & Noble, B. Dalton, Bookland, Books-a-Million, Books & Co., Bookstar, Bookstop, Borders, Brentano"s, Coles, Coopersmith, Doubleday, Scribners and Waldenbooks stores, as well as sales from online retailers Amazon.com and barnesandnoble.com.< /p> ,,,

Asking For -- and Maximizing -- the Informational Interview

Do all the employees at your dream company have an MBA? What is a typical day like in a big-city newsroom? What types of questions might someone be asked when interviewing for a position in the health-care industry? 

If you"ve got questions about a career, an informational interview might be your ticket to answers. 

"An informational interview can help you better understand a career, industry, company, organization or specific position you are potentially interested in by finding out what really goes on behind the scenes versus what you"ve heard or what you imagine," says Debra Condren, author of "Ambition Is Not a Dirty Word," a career guide for women. "Having a more accurate picture will help you decide if this career target really matches your talents, passion, interests, strengths and weaknesses. It will also inform your choice of education and training." 

How to askFor many people, the prospect of making a blind call to a place of interest can be daunting. It also might not be very fruitful. A better idea is to network your way into an informational interview. 

"The best approach is to brainstorm about someone you know who may work in the industry or company you"re targeting," Condren states. "Does your parent, brother, best friend, roommate or someone you went to college with know someone who knows someone who would send an e-mail on your behalf asking if it"s OK for you to contact them?" 

Alumni offices and college career centers also can be good places to turn. James Greeley, director of career services and cooperative education at Merrimack College in North Andover, Mass., notes that his institution routinely provides informational interview services for students and graduates. "The programs are staffed by human resource personnel and hiring managers from a variety of corporations as well as Merrimack College alumni who volunteer to offer their expertise and assistance." 

When picking up the phone or writing to someone to set up an informational interview, Condren recommends the following to help things run smoothly: 

Mention your mutual connection. Ask for a precise amount of time. (As in, "I was wondering if I could have fifteen minutes of your time.") Approach the person with two or three very specific questions. (As in "I"m interested in your opinion on which majors train you best for this field.") It gives the interviewer a preview of what you want to discuss and shows that you have taken the initiative to define what you"re trying to accomplish.

Treat it like a job interviewIf you are interested enough in a field or a company to set up an informational interview, there is a chance that down the line you might want to use this connection when seeking employment. Make a good first impression by:

Dressing professionally Treating everyone you encounter politely Arriving early Doing your homework; you should be asking for insight, not basic information available on a Web site Preparing a list of questions that gets at exactly what you want to know

While it may seem that you are the one with everything to gain from an informational interview, remember that companies also can benefit. "We"re always looking for top talent, and an informational interview is another chance to meet a potential candidate," says Holly Paul, national recruiting leader for PricewaterhouseCoopers, one of the world"s largest professional services firms. "It provides an opportunity for us to share what we do and learn how the candidate might fit into our organization."

Express gratitudeThe person who granted the informational interview provided a valuable service and should be thanked accordingly for sharing her time and expertise. While a timely e-mail is considered acceptable by some experts, a mailed note may be better.

"Sending an old fashioned hand-written card will make you stand out," Condren states. "It saves the person who did the interview from having to open one more in his or her daily gazillion e-mails."

Finally, remember to keep the lines of communication open for future contact. How to do this without becoming a pest? Paul suggests that before the interview even ends that you ask how you should follow-up, and then follow that advice. Later, take a moment in your thank-you note to restate your interest in potential future opportunities. A small, but genuine, gesture now can be a building block for bigger things to come.